Kentucky's ongoing attempt to end racing in state proceeds..

[RolloTomasi]

Originally Posted by Riot

Yes. Research shows a decrease in red blood cells and hemosiderophages via transtracheal washes post lasix vs. without lasix.

Is decreasing the severity of bleeding the same as stopping bleeding?

[Riot]

Originally Posted by RolloTomasi

Is decreasing the severity of bleeding the same as stopping bleeding?

Not necessarily - sometimes lasix makes it less, sometimes it makes it stop completely, sometimes it doesn't do anything. Overall yes, lasix vastly reduces the incidence of detection of bleeding due to EIPH in horses, including stopping it in some horses.

Here's a cross section of lung (viewing it from the horses left side, the front of the horse is on the left) showing where bleeding occurs, the top (dorsal) back (caudal) part of the lung. We only detect blood when it comes out of the lungs up into the trachea. The trachea isn't shown here, it would be to the left of the lungs:





Here's a horse bleeding so bad blood is bubbling out of the lungs, up the trachea, and out the nose. Only 1 out of 20 will bleed so badly this is seen:



Here's a horse with a little blood in the trachea via bronchoscopy:

[RolloTomasi]

Originally Posted by Riot

Overall yes, lasix vastly reduces the incidence of detection of bleeding due to EIPH in horses, including stopping it in some horses.

So the majority of horses treated with lasix do not bleed?

[Riot]

Originally Posted by RolloTomasi

So the majority of horses treated with lasix do not bleed?

The majority have their previously documented level of bleeding markedly decreased or gone, as evidenced by bronchoscopy clinically and BAL/TTW in research. Lasix does not work in all horses, some are unaffected.

The origins and causes of EIPH are thought to be multifactorial. In the 1990's I worked on the research that first measured actual cardiopulmonary intravascular pressures in horses while galloping at racing speed both on and off lasix. Lasix decreases the exercise-induced increase in cardiac and pulmonary pressures. High blood pressure rupturing fragile capillaries in the lung has always been one suspected cause of EIPH.

Chronic airway inflammation predisposing to capillary failure is another. I'd love to study the lungs of horses that live year-round at Churchill Downs, bordered by highways and under airport plane exhaust.

Another is the physical pounding, and physics: the sheer forces created within the lung tissue as a horse gallops a long time over firm ground carrying weight.

Another is the huge variance in intrapulmonary airway pressures, upper vs lower, during massive air intake of exercise - why the Flair nasal strips which hold the upper airway open decrease EIPH as much as lasix in some horses.

[Riot]

Cannon wrote: I have no doubt that horses treated aggressively with gastrogard for stomach ulcers perform far greater than those who arent treated but because those horses are not designated no one talks about that. Using the logic that some do, Gastrogard would be considered a performance enhancer as well.

That's a very good analogy, actually.

I cannot consider lasix a performance enhancer any more than preventative inhaler asthma meds are for a running athlete who happens to have asthma. Lasix enables a horse to run to their peak, by helping prevent the development of a medical condition that will inhibit running ability by suffocating the horse in it's own blood to a lesser or greater degree.

[RolloTomasi]

Originally Posted by Riot

Lasix enables a horse to run to their peak, by helping prevent the development of a medical condition that will inhibit running ability by suffocating the horse in it's own blood to a lesser or greater degree.

But doesn't lasix have other systemic effects besides reducing the severity of bleeding that may improve performance? At the same time, does lung bleeding necessarily preclude a horse from performing competitively?

[Riot]

Originally Posted by RolloTomasi

But doesn't lasix have other systemic effects besides reducing the severity of bleeding that may improve performance?

It can cause a small weight loss via diuresis (causing peeing), but research doesn't seem to support that the weight loss is contributory to any improved performance (there was a study that repeated everything with and without lasix with also replacing the weight lost by the horse due to lasix).

Lasix is the same "water pill" people take who have cardiac problems. Used in a one-time prerace injection, it won't cause a massive weight loss, it doesn't cause massive dehydration, it doesn't cause massive electrolyte problems (unless a trainer is really screwing with stuff by also spiking electrolytes in an excessive manner, or withholding water from the horse for 24 hours, etc)

Its funny - watching Australian racing, the temps there have been hot lately, and horses are literally wringing water off their bodies by the time they get to the post. We don't see that on horses using lasix to that extent (sweating is cooling) - but I'll bet those horses lose 20-30 pounds in water weight, too, before a race.

At the same time, does lung bleeding necessarily preclude a horse from performing competitively?

If your lungs are filled with mucus from a cold, can you breath? Can you do your 2-3 miles of daily roadwork? Can you inhale deeply and oxygenate yourself successfully under maximal physical effort?

Depends upon the amount of stuff down in your smallest airways and alveolar sacs, right?

[cmorioles]

Originally Posted by Riot

That's a very good analogy, actually.

I cannot consider lasix a performance enhancer any more than preventative inhaler asthma meds are for a running athlete who happens to have asthma. Lasix enables a horse to run to their peak, by helping prevent the development of a medical condition that will inhibit running ability by suffocating the horse in it's own blood to a lesser or greater degree.

I would buy that if it wasn't used so liberally. I'll just never believe that every horse in North America needs it, yet they get it anyway. Since it isn't free, it seems a lot of trainers feel they need it to level the playing field, i.e. it enhances performance.

Many of the European horses that don't need it ship for the BC and they get it anyway. Why is that? European trainers seem to think it is a performance enhancer. Are they just uneducated? The ones that don't get it rarely run to their odds. Just coincidence?

[Riot]

Anyone can poke around at www.ncbi.nlm.nih.gov

Use EIPH and race horse as your search terms

I found these with EIPH furosemide speed as the search terms

J Am Vet Med Assoc. 1999 Sep 1;215(5):670-5.

Effect of furosemide on performance of Thoroughbreds racing in the United States and Canada.

Gross DK, Morley PS, Hinchcliff KW, Wittum TE.
Source

Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
Abstract

OBJECTIVE: To determine the effect of furosemide on performance of Thoroughbreds racing on dirt surfaces at tracks in the United States and Canada.

DESIGN: Cross-sectional study.

ANIMALS: All Thoroughbreds (n = 22,589) that finished a race on dirt surfaces at tracks in the United States and Canada between June 28 and July 13, 1997 in jurisdictions that allowed the use of furosemide.

PROCEDURE: Race records were analyzed by use of multivariable ANOVA procedures and logistic regression analyses to determine the effect of furosemide on estimated 6-furlong race time, estimated racing speed, race earnings, and finish position. Principal component analysis was used to create orthogonal scores from multiple collinear variables for inclusion in the models.

RESULTS: Furosemide was administered to 16,761 (74.2%) horses. Horses that received furosemide raced faster, earned more money, and were more likely to win or finish in the top 3 positions than horses that did not. The magnitude of the effect of furosemide on estimated 6-furlong race time varied with sex, with the greatest effect in males.

When comparing horses of the same sex, horses receiving furosemide had an estimated 6-furlong race time that ranged from 0.56 +/- 0.04 seconds (least-squares mean +/- SE) to 1.09 +/- 0.07 seconds less than that for horses not receiving furosemide, a difference equivalent to 3 to 5.5 lengths.

CONCLUSIONS AND CLINICAL RELEVANCE:

Because of the pervasive use of furosemide and its apparent association with superior performance in Thoroughbred racehorses, further consideration of the use of furosemide and investigation of its effects in horses is warranted.

http://www.ncbi.nlm.nih.gov/pubmed/10476714

Am J Vet Res. 1990 May;51(5):772-8.

Effects of furosemide on the racing times of Thoroughbreds.

Sweeney CR, Soma LR, Maxson AD, Thompson JE, Holcombe SJ, Spencer PA.
Source

Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
Abstract

The effects of furosemide on the racing times of 79 horses without exercise-induced pulmonary hemorrhage (EIPH) and 52 horses with EIPH were investigated.

Racing times were adjusted to 1-mile equivalent racing times by 2 speed handicapping methods, and analysis of covariance was used to adjust actual racing times by winning time and distance for each race.

All 3 methods of determining racing time indicated that geldings without EIPH had significantly faster racing times (P less than 0.05) when given furosemide before racing than when furosemide was not given before racing.

Females and colts without EIPH were determined to have faster racing times when furosemide was given before racing, but the difference was not significant.

Geldings with EIPH had significantly faster racing times (P = 0.0231) when given furosemide before racing, as determined by one of the speed handicapping methods.

There was a strong correlation (range 0.9314 to 0.9751) between the 1-mile equivalent racing times, as determined by the 2 speed handicapping methods for horses with and without EIPH.

Furosemide failed to prevent the development of EIPH in many horses that were previously considered to be EIPH-negative.

When given furosemide, 62 (25.3%) of 235 EIPH-negative horses were EIPH-positive after racing.

Furosemide had questionable efficacy for prevention of EIPH in known EIPH-positive horses.

Thirty-two (61.5%) of 52 EIPH-positive horses given furosemide before a race remained EIPH-positive after that race.

http://www.ncbi.nlm.nih.gov/pubmed/2337276

Am J Vet Res. 1980 Aug;41(8):1183-9.

Effects of furosemide on cardiovascular function and performance when given prior to simulated races: a double-blind study.

Milne DW, Gabel AA, Muir WW, Skarda RT, Hamlin RL, Pipers FS.
Abstract

In a double-blind study under simulated racing conditions, six Standardbred horses, which had been trained for 12 weeks, were given 1 mg of furosemide/kg of body weight or saline solution IV 15 minutes before the first of two warm-up workouts (1.6 km at 60-minute intervals).

Sixty minutes later, 135 minutes after drug or placebo injection, these horses were driven 1.6 km at maximum speed.

Heart rate, respiratory rate, cardiac output, pulmonary trunk pressure, body temperature, PCV, arterial oxygen, and plasma lactic acid were recorded during and after the first warm-up workout and after a simulated race (1.6 km).

Values increased compared with values determined at rest whether saline solution or furosemide was given.

There were decreases in arterial CO2 and pH. When furosemide was given, the pulmonary trunk pressure was significantly lower (P < 0.05) during the first warm-up workout (1.6 km). There were no significant differences in the other values.

The average times of the simulated races were not significantly (P < 0.05) different after the use of furosemide compared with average times after use of saline solution.

http://www.ncbi.nlm.nih.gov/pubmed/6778267

[Danzig]

Originally Posted by cmorioles

I would buy that if it wasn't used so liberally. I'll just never believe that every horse in North America needs it, yet they get it anyway. Since it isn't free, it seems a lot of trainers feel they need it to level the playing field, i.e. it enhances performance.

Many of the European horses that don't need it ship for the BC and they get it anyway. Why is that? European trainers seem to think it is a performance enhancer. Are they just uneducated? The ones that don't get it rarely run to their odds. Just coincidence?

but aren't many using it because of what it prevents? horses can have an episode without having given a previous warning. i know some horses have had a significant amount of bleeding and have never bled before.

[Cannon Shell]

Originally Posted by cmorioles

I would buy that if it wasn't used so liberally. I'll just never believe that every horse in North America needs it, yet they get it anyway. Since it isn't free, it seems a lot of trainers feel they need it to level the playing field, i.e. it enhances performance.

Many of the European horses that don't need it ship for the BC and they get it anyway. Why is that? European trainers seem to think it is a performance enhancer. Are they just uneducated? The ones that don't get it rarely run to their odds. Just coincidence?

Dont take offense but you are just guessing here. How can anyone determine what horses need or dont need lasix unless you can accurately pinpoint when a horse may have a bleeding episode? Trainers use it because it is a cheap, easy way to help your horse NOT bleed and with those who have bled before to try to prevent another episode. I'm sure you will counter with they can still bleed through lasix or it isnt proven to prevent bleeding (though I dont know how you could prove that given you rarely have any clue when your horse may bleed) but it is still a pretty effective, easy to use medication with few side effects. It isn't unlike wearing a seatbelt. A seatbelt might not save your life in a car wreck everytime but you sure do increase your chances with one.

[Rupert Pupkin]

Originally Posted by Riot

The majority have their previously documented level of bleeding markedly decreased or gone, as evidenced by bronchoscopy clinically and BAL/TTW in research. Lasix does not work in all horses, some are unaffected.

The origins and causes of EIPH are thought to be multifactorial. In the 1990's I worked on the research that first measured actual cardiopulmonary intravascular pressures in horses while galloping at racing speed both on and off lasix. Lasix decreases the exercise-induced increase in cardiac and pulmonary pressures. High blood pressure rupturing fragile capillaries in the lung has always been one suspected cause of EIPH.

Chronic airway inflammation predisposing to capillary failure is another. I'd love to study the lungs of horses that live year-round at Churchill Downs, bordered by highways and under airport plane exhaust.

Another is the physical pounding, and physics: the sheer forces created within the lung tissue as a horse gallops a long time over firm ground carrying weight.

Another is the huge variance in intrapulmonary airway pressures, upper vs lower, during massive air intake of exercise - why the Flair nasal strips which hold the upper airway open decrease EIPH as much as lasix in some horses.

Speaking of pollution that the horses are breathing, I know that it would be expensive but wouldn't it be much better for the horses' lungs if the barn areas were re-done at all the tracks. At most tracks, the whole barn area is dirt. Why not put grass down everywhere and then pave the paths with that rubber brick stuff. Inside the barns, they could put down that rubber brick surface too.

I would have to think the horses would be less likely to bleed if their lungs weren't filled with all the dust that they breathe in all day in the barn area.

At Oaklawn Park they have a lot of grass in the barn areas. I would have to think that is much better than all that dirt and dust.

[Riot]

Originally Posted by Rupert Pupkin

Speaking of pollution that the horses are breathing, I know that it would be expensive but wouldn't it be much better for the horses' lungs if the barn areas were re-done at all the tracks. At most tracks, the whole barn area is dirt. Why not put grass down everywhere and then pave the paths with that rubber brick stuff. Inside the barns, they could put down that rubber brick surface too.

I would have to think the horses would be less likely to bleed if their lungs weren't filled with all the dust that they breathe in all day in the barn area.

At Oaklawn Park they have a lot of grass in the barn areas. I would have to think that is much better than all that dirt and dust.

Horse airways are designed to work with the horse's head down in the clean, green grass, grazing.

Most non-racing barns feed hay on the ground for that reason. Tracks determine if a trainer can use straw (can have alot of molds) or shavings to bed. Off track some people use newspaper or simply rubber mats for bedding allergic horses.

Yeah, horses inhaling all that dust from gravel drives and dirt on the track isn't as good as not doing it.

Those pavers are high dollar items.

Hey - for a mere less than 2 million, you can purchase this place next to the TB Training Center in Lexington, and have all your horses out getting grass time daily!

http://www.biedermanbrokerage.com/ (third property down on Paris Pike)