Sudden Deaths in Southern Cal

[docicu3]

Originally Posted by Calzone Lord

You knew Joe Drape would be all over this.

This is the only type of racing story he seems to like.

http://www.nytimes.com/2013/04/11/sp...=tw-share&_r=0

Doug

In the human world we "overshoot" coumadin or warfarin doses all the time which is easily treated by Vit K or time, often the problem isn't the drug but whatever else is eaten with the meal which can either shorten or lengthen the half life of the drug since they all work by interfering with Vit K metabolism or the liver dependent coagulation factors.

Vitamin K is used in the body to form bones but also plays an important role in blood clotting. Coumadin works by interfering with the liver synthesis of vitamin K-dependent clotting factors. Vit K decreases the amount of blood clots formed in the body the opposite of what your drugs in the article do.

In humans we use these meds to stop clotting for a bunch of reasons such as stroke prevention or avoiding clot associated with abnormal heart rythmns but yes these are the same class and effect of drugs.

[Clip-Clop]

Originally Posted by docicu3

Doug

In the human world we "overshoot" coumadin or warfarin doses all the time which is easily treated by Vit K or time, often the problem isn't the drug but whatever else is eaten with the meal which can either shorten or lengthen the half life of the drug since they all work by interfering with Vit K metabolism or the liver dependent coagulation factors.

Vitamin K is used in the body to form bones but also plays an important role in blood clotting. Coumadin works by interfering with the liver synthesis of vitamin K-dependent clotting factors. Vit K decreases the amount of blood clots formed in the body the opposite of what your drugs in the article do.

In humans we use these meds to stop clotting for a bunch of reasons such as stroke prevention or avoiding clot associated with abnormal heart rythmns but yes these are the same class and effect of drugs.

Would diphacinone interfere with the liver as well? TAP had a liver issue going with a few horses a couple years ago that a cause was never really determined, if I remember.

This is from the studyon E X T O X N E T. Interesting that it would be fed to animals to keep bats away...

"Fate in humans and animals: Rats eliminated 70% of the administered oral dose via the feces and 10% in the urine within 8 days [172]. A similar pattern of elimination occurred in mice [172]. Animal studies indicate that little metabolism takes place, and that diphacinone which is not eliminated may concentrate to varying degrees in the liver, kidneys, and lungs [8,172]. The half-life of diphacinone in humans is 15 to 20 days [8]. It was determined that cattle dosed with the compound as an anti-bat measure were safe to use for dairy and/or meat production [8]."

[Danzig]

Originally Posted by docicu3

Doug

In the human world we "overshoot" coumadin or warfarin doses all the time which is easily treated by Vit K or time, often the problem isn't the drug but whatever else is eaten with the meal which can either shorten or lengthen the half life of the drug since they all work by interfering with Vit K metabolism or the liver dependent coagulation factors.Vitamin K is used in the body to form bones but also plays an important role in blood clotting. Coumadin works by interfering with the liver synthesis of vitamin K-dependent clotting factors. Vit K decreases the amount of blood clots formed in the body the opposite of what your drugs in the article do.

In humans we use these meds to stop clotting for a bunch of reasons such as stroke prevention or avoiding clot associated with abnormal heart rythmns but yes these are the same class and effect of drugs.

what else would be affected? would it affect overall metabolism? would there be anything beneficial from using blood thinners for someone/thing in high activity?

[Danzig]

i did a search on blood thinners as performance enhancers, and i found this:

"Blood Viscosity
Like anything else, the thicker blood is, the slower it moves through the body. So anything that reduces the viscosity of blood is going to make it easier for the heart to get a full charge, faster for the heart to eject and quicker to deliver oxygen and remove heat, lactic acid and CO2. On a microscopic scale, at the entrance to capillaries, red blood cells tend to stack up like a traffic jam. This can reduce oxygen delivery. Thinning the blood a little can break up these traffic jams and improve flow. Red blood cells are less sticky when blood is thinned so you get more flowing through capillaries and delivering oxygen.

Secret Weapon #2 - Salycin
Although there are a number things you can take that reduce the viscosity of blood, the one we like best is a natural extract of willow bark called Salycin. As you may have guessed, it is related to Asprin (acetyl-salycilic acid). All blood thinners work about the same, by reducing cell-to-cell stickiness. Salycin is nice because you get all the performance enhancement without the risks inherent in more aggressive blood thinners. "