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![]() found this while trying to find info on lasix in foreign countries:
Long Term Lung Changes in ‘Bleeders’ It is well known that once a horse has a ‘severe’ bleed, it’s subsequent race performance is likely to be reduced. The upper, back sections of the lung receive high blood flow during exercise, and is the area which exhibits evidence of vascular changes and long term damage following a severe ‘bleeding’ episode. Prof. Frederik Derksen and other leading, well known researchers at Michigan State and Melbourne University, investigated the effects of bleeding on lung pathology. It is currently believed that bleeding (or Exercise-Induced Pulmonary Haemorrhage (EIPH) results from high internal blood pressures (hypertension) and stress failure of the walls of the lung airsac (alveolar) capillary arteries in all-out pacing and galloping horses. However, the pathological changes that would be expected in this case, with vessel fibrosis, blockage and small bypass vessels that form within the bronchial walls, were not as severe as previously identified. The new Michigan study identified significant lung vascular changes, including increased vein hypertension in the lung drainage vessels after a ‘bleeding’ episode. It was also found that both lungs had similar changes, despite previous findings that the hind lobes of the left lung were more scarred following a severe ‘bleed’. The study found more collagen ‘scar’ tissue or fibrosis, degenerative red cell/monocyte accumulation (haemosiderin) and vascular remodelling in the airsac lining vessels in both the capillaries and drainage veins, as well as the separating elastic (interstitial) tissues. The diameter of the supply and drainage vessels were decreased by greater than 50% during the healing process. This could be the reason for the poor performance after a ‘bleed’, with increased lung fluid build-up (oedema) and lower oxygen uptake. Editor’s Note: The study indicated that restriction of the veins in the area most effected by a ‘severe’ bleed, may underlie the other damage seen after a ‘bleed’ and reduce subsequent performance by affecting lung efficiency in the long term. Restricting water intake for 6 hours prior to racing may also help to reduce lung oedema and fluid retention. i'd want to prevent a bleed that would cause lasting damage. what would you tell me to do instead, if i was worried about such a thing, knowing the drug has medical uses and can prevent unnecessary damage to a horse that someone potentially invests a lot of money in? if your concern is that it could move a horse up, but most horses already use it anyway, doesn't that negate any possible move-up? and many articles i've read say it's not a performance enhancer. is that an opinion, and not a proven fact? from what i've read in various studies, it's not a fact.
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Books serve to show a man that those original thoughts of his aren't very new at all. Abraham Lincoln Last edited by Danzig : 04-29-2012 at 10:39 AM. |