Most Gr 1 wins by a female against males

[cmorioles]

Since races have only been graded since 1973, that is going to limit it a bunch.

Dahlia won three, and it is more impressive because they were in 1973, 74 and 76 and mixed in several G1 wins overseas against males as well.

All Along won three straight G1s after her Arc win, but one of those was in Canada so I guess she doesn't qualify.

Probably the most impressive brief run was April Run. She won the Turf Classic and the DC International by simply demolishing both fields, almost unheard of in G1 turf routes.