Quote:
Originally Posted by OTM Al
I'm talking about weight and nothing more. Got my own feelings about where that water loss comes from when it is drug induced vs sweating from practical and observational experience, but am no vet and am not going to argue on one side or the other of this agenda driven debate.
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This debate is agenda-driven by the welfare of racing horses, and what is best for their health, as far as I am concerned.
Lasix a loop diuretic that acts on the kidney. It makes you form urine via osmosis.
We have a very long history and frequent common use in people and animals, with reams of pharmacologic research. We know virtually everything about this drug. So have lots of experience in exactly what water is lost when a person or animal gets a lasix shot.
It is first intravascular water from blood plasma, and as that is lowered, extracellular water is drawn into blood plasma. That's "free water" sitting in tissues between cells. Not within the cells. But one shot of lasix doesn't affect extracellular water, and barely affects plasma water.
That is why lasix is used for lung edema and hypertension in congestive heart failure in humans, to decrease lung secretions in some pneumonias, and to decrease EIPH in race horses.
Here's the thing: as soon as the businessman leaders of racing start talking about the pharmacologic medical effects of lasix, and using those as arguments, they have to defer to the far more educated medical veterinary world to tell them how the drug works. Some refuse to do that if the medical facts go against their goal or opinion. That's absurd. The only interest the veterinary world has in this fight is the welfare of the horse.
Vets sit at the sidelines of this fight, puzzled, offering up the scientific truth to the horse world about what lasix does and doesn't do when they are asked, and giving results of the hundreds of thousands of dollars of research on lasix in race horses we have done - and then sit while lay people unhappy with the results science has found argue with what they learn as if it's debatable, as if simply denying it can make it false, and using animal rights activists and personal opinion as counters to science.
There is opinion. There is fact. They are different. There is considered opinion formed after full exposure to the facts. But denying facts exist in order to continue to hold an opinion is exactly what some in the racing industry are doing now, and that's stupid.