If she stays healthy and is on form she will run against boys again, or Zenyatta, or both, so just chill.
And to "ateamstupid" who asked:
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How do you know what's in the best interest of the horse?
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If Jess Jackson tells me it is in her best interest not to run, then a fortiori just about anyone else can say the same thing with a HIGH level of confidence.