Sorry but the pancreas creates insulin. The spleen, in a horse, is a storage unit for red blood cells. Yes, they can live without it, but he can't run. The problem is if this is lymphoma, it is probably NOT just in the spleen. Lymphoma's usually also need chemotherapy treatment as it travels by white blood cells. Spleen surgery in a horse is also uncommon. I know they will try but things ain't looking good.
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